Grapefruit’s Bitter Taste Holds a Sweet Promise for Diabetes Threrapy
The antioxidant naringenin, which is derived from bitter part of citrus fruits such as grapefruit, may cause the liver to break down fat and increase insulin sensitivity, report a research team from the Hebrew University of Jerusalem and Massachusetts General Hospital in Boston. Naringenin, the scientists say, activates nuclear receptors and may actually imitate the actions of other drugs such as fenofibrate and rosiglitazone. Further study is required to confirm these benefits, but if this is accomplished, the compound could be used to treat hyperlipidemia, type 2 diabetes, and metabolic syndrome. The team reports its findings in the journal PLoS ONE. “It is a fascinating find,” says senior author Yaakov Nahmias of the Hebrew University of Jerusalem. “We show the mechanism by which naringenin increases two important pharmaceutical targets, PPARalpha and PPARgamma, while blocking a third, LXRa. The results are similar to those induced by long periods of fasting.”
(c)
Similar Posts:
- ADRA2A gene polymorphisms are associated with type 2 diabetes risk and metabolic traits
- Coffee May Reduce Diabetes Risk
- Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
- Low glycemic diet is more effective than low fat diet in reducing HbA1c in obese T2DM patients
- NIH Announces New Strategic Plan to Combat Diabetes
Recent Comments